ORMDL2 and CD79A

Data Source:
BioGRID (two hybrid)

		ORMDL2	CD79A
Description		ORMDL sphingolipid biosynthesis regulator 2	CD79a molecule
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane SPOTS Complex	Multivesicular Body Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane B Cell Receptor Complex Membrane Raft
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process	Adaptive Immune Response B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis	CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		21 interacting genes: AQP6 CD79A CREB3L1 CYB561 CYB5R3 DAPK1 EBP ELOVL4 FAM210B FCER1G GJA8 KCNJ6 MMGT1 RETREG3 SCN3B SLC10A1 TMEM120A TMEM31 TMEM86B TMX2 ZDHHC15	181 interacting genes: ADIPOQ AGTRAP ALG10 ALG10B ALG3 APOD AQP1 AQP3 ATP6V0C BCL2L2 BET1 BLK BLNK BRICD5 BTN2A2 C14orf180 C1GALT1 C2CD2L C4orf3 CCDC167 CD19 CD5 CD79B CDIPT CLDN1 CLN6 CMTM5 CMTM7 CNIH1 CNIH3 COL4A5 CTSA CTXN3 CYB561 CYB561A3 CYB561D2 CYB5B DEFB127 DOLK EDDM3B EMC6 EMP1 EMP3 FA2H FAM241B FANCA FATE1 FAXDC2 FCAR FDFT1 FFAR3 FKBP8 FUNDC2 FXYD3 FYN GALNT15 GIMAP1 GJB1 GPR42 HACD4 HCLS1 HMOX1 HMOX2 IER3 IGHM INSIG2 ITGAM JAGN1 JCHAIN LAMB1 LCK LEPROTL1 LHFPL5 LPAR3 LTC4S LYN MALL MARCHF2 MFF MFSD12 MFSD5 MFSD6 MGLL MMD2 MOSPD3 MS4A13 MYADM MYADML2 NAT8 NEU1 NINJ2 NIPAL3 NKG7 ORMDL2 OTOP2 PGAP2 PIGR PKMYT1 PLP2 PLPP6 PLPPR2 PNLIPRP1 PRAF2 PTCH1 PTPN6 REEP6 RHO RTP2 SACM1L SEC22B SERP1 SFTPC SLC13A4 SLC13A5 SLC16A12 SLC16A13 SLC30A2 SLC35B1 SLC35B4 SLC38A1 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC46A3 SLC66A2 SLC6A12 SLC7A1 SMCO4 SMIM3 STRIT1 STX12 STX3 STX8 SYK SYNJ2BP TECR THBD TM4SF19 TM4SF4 TMBIM6 TMEM107 TMEM11 TMEM128 TMEM140 TMEM147 TMEM14B TMEM176A TMEM187 TMEM19 TMEM218 TMEM222 TMEM229B TMEM239 TMEM243 TMEM254 TMEM262 TMEM42 TMEM86A TMEM86B TMPPE TNFRSF10C TRAM1L1 TRARG1 TSNARE1 TSPAN2 TSPO2 UBE2J1 UBIAD1 UNC93B1 VAMP3 VAPA VAPB VTI1B WFDC2 WFS1 YIF1A YIPF4 YIPF6 ZDHHC15 ZDHHC22
Entrez ID		29095	973
HPRD ID		17802	00203
Ensembl ID		ENSG00000123353	ENSG00000105369
Uniprot IDs		Q53FV1	P11912
PDB IDs			1CV9
Enriched GO Terms of Interacting Partners?
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