MED4 and SMARCD1

Data Source:
BioGRID (two hybrid, biochemical, two hybrid)

		MED4	SMARCD1
Description		mediator complex subunit 4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle NpBAF Complex NBAF Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Chromatin-mediated Maintenance Of Transcription Cellular Response To Fatty Acid
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 SYCE2 TLE5 TNFAIP8 TNFAIP8L1 TXLNA TXLNB USHBP1 WDTC1	156 interacting genes: ABI1 ABI2 ABI3 ADAT2 ANKRD23 ANKRD49 ANKS1A ANP32B APOA5 AR ARMC10 ARRDC3 BCAS2 BEND5 BEX3 BHLHB9 BLOC1S5 BRWD1 C19orf54 C1orf109 C4BPA CALCOCO2 CCDC102B CCDC130 CCDC197 CCDC33 CCDC85B CDC5L CDR2 CDSN CDX2 CEACAM6 CHFR CHN2 CLNK COG6 COL1A2 CORO1A CUEDC1 CYSRT1 DCTN2 DISC1 EGFL7 EIF4G1 ESR1 ESS2 FAM136A FAM161A FBXO7 FEZ1 FOS FUS GATA1 GCC1 GIGYF1 GINS3 GOLGA6L9 GRAMD4 HES6 HNRNPC HOMEZ HOXD3 HSF2BP HSPB1 IGKC IKBIP IKZF3 INSC IQCB1 JUN KATNBL1 KDM1A KEAP1 KIAA0753 KLF1 KMT5B KRT15 KRT16 KRT18 KRT27 KRT31 KRT34 KRT37 KRT38 KRT75 LDB2 LDOC1 LZTS2 MAGEA2 MAGEA2B MAGEA6 MED4 MKRN3 MTNR1B MTUS2 NAB2 NECAB2 NELFA NME1 NONO NR1H4 NR3C1 NUCB2 NUDT16L1 NUTM1 PACSIN3 PAICS PBX4 PCBD1 PGR PICK1 PIH1D1 PKNOX2 PLAGL2 PPM1J PRDX1 PRMT6 PSTPIP1 RIF1 RORB RPS29 SCARA5 SCHIP1 SCNM1 SERTAD3 SHISA6 SMARCB1 SMUG1 SNF8 SPSB2 STH STMN3 SYCE1L TCP10L THOC7 TLE5 TNIP2 TP53 TRIM27 TRIM54 TRIM72 USHBP1 USP54 VPS37B WASHC1 WWP2 YWHAG ZC2HC1C ZMAT5 ZMYND12 ZNF417 ZNF438 ZNF511 ZNF629 ZNF655 ZNF69
Entrez ID		29079	6602
HPRD ID		16145	03438
Ensembl ID		ENSG00000136146	ENSG00000066117
Uniprot IDs		A0A024RDY7 Q9NPJ6	Q96GM5
PDB IDs			6LTH 6LTJ
Enriched GO Terms of Interacting Partners?
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