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C1GALT1C1 and LGALS3
Data Source:
BioGRID
(pull down)
C1GALT1C1
LGALS3
Description
C1GALT1 specific chaperone 1
galectin 3
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Integral Component Of Membrane
Extracellular Exosome
Immunological Synapse
Extracellular Region
Extracellular Space
Nucleus
Spliceosomal Complex
Cytoplasm
Mitochondrial Inner Membrane
Plasma Membrane
Cell Surface
Membrane
Secretory Granule Membrane
Collagen-containing Extracellular Matrix
Extracellular Exosome
Ficolin-1-rich Granule Membrane
Molecular Function
Protein Binding
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity
RNA Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
IgE Binding
Protein Phosphatase Binding
Carbohydrate Binding
Chemoattractant Activity
Laminin Binding
Biological Process
Protein O-linked Glycosylation
O-glycan Processing
O-glycan Processing, Core 1
Protein Phosphopantetheinylation
Platelet Activation
Platelet Morphogenesis
Monocyte Chemotaxis
MRNA Processing
RNA Splicing
Neutrophil Chemotaxis
Epithelial Cell Differentiation
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of T Cell Proliferation
Neutrophil Degranulation
Innate Immune Response
Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Endocytosis
Eosinophil Chemotaxis
Macrophage Chemotaxis
Negative Regulation Of T Cell Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of T Cell Apoptotic Process
Mononuclear Cell Migration
Positive Regulation Of Mononuclear Cell Migration
Positive Regulation Of Calcium Ion Import
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Protein Tyrosine Phosphatase Activity
Negative Regulation Of Immunological Synapse Formation
Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Positive Regulation Of Dendritic Cell Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
O-linked glycosylation of mucins
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX2 regulates genes involved in differentiation of myeloid cells
Drugs
2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide
Lactose
Diseases
GWAS
Serum galactose-deficient IgA1 levels (
28187132
)
Blood protein levels (
30072576
28240269
)
Blood protein levels in cardiovascular risk (
28369058
)
Leukoderma in response to rhododendrol (
32558222
)
Protein biomarker (
23056639
)
Testicular germ cell tumor (
28604728
)
Interacting Genes
3 interacting genes:
B3GNT2
C1GALT1
LGALS3
28 interacting genes:
APP
C1GALT1C1
CRX
CSNK1A1
CSNK2A1
CSNK2A2
CUBN
CYHR1
ELN
FCGR2A
GEMIN4
GOLGA2
INCA1
KIF16B
LGALS3BP
LIM2
MCPH1
MEFV
MMP2
MYOC
PPIG
PRR13
SS18L1
SUFU
TRIM17
TRIM22
TRIM23
TRIM6
Entrez ID
29071
3958
HPRD ID
06462
01090
Ensembl ID
ENSG00000171155
ENSG00000131981
Uniprot IDs
Q96EU7
A0A024R693
P17931
PDB IDs
1A3K
1KJL
1KJR
2NMN
2NMO
2NN8
2XG3
3AYA
3AYC
3AYD
3AYE
3T1L
3T1M
3ZSJ
3ZSK
3ZSL
3ZSM
4BLI
4BLJ
4BM8
4JC1
4JCK
4LBJ
4LBK
4LBL
4LBM
4LBN
4LBO
4R9A
4R9B
4R9C
4R9D
4RL7
4XBN
5E88
5E89
5E8A
5EXO
5H9P
5H9R
5IUQ
5NF7
5NF9
5NFA
5NFB
5NFC
5OAX
5ODY
6B8K
6EOG
6EOL
6EXY
6EYM
6F2Q
6F6Y
6FK2
6FOF
6G0V
6H64
6I74
6I75
6I76
6I77
6I78
6KXA
6KXB
6Q0Q
6Q17
6QGE
6QGF
6QLN
6QLO
6QLP
6QLQ
6QLR
6QLS
6QLT
6QLU
6RHL
6RHM
6RZF
6RZG
6RZH
6RZI
6RZJ
6RZK
6RZL
6RZM
6Y4C
6Y78
Enriched GO Terms of Interacting Partners
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