CCDC113 and PFN2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CCDC113	PFN2
Description		coiled-coil domain containing 113	profilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Axoneme Protein-containing Complex Centriolar Satellite Ciliary Basal Body	Cytoplasm Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity
	Biological Process	Cilium Assembly	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways			Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			Triglyme Pentaglyme
Diseases
GWAS		Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 28714469)	Fish- and plant-related diet ( 32066663)
Interacting Genes		6 interacting genes: GIT1 HAP1 HSF2BP IMMT PFN2 SMYD1	34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		29070	5217
HPRD ID		07121	01451
Ensembl ID		ENSG00000103021	ENSG00000070087
Uniprot IDs		Q9H0I3	P35080
PDB IDs			1D1J
Enriched GO Terms of Interacting Partners?
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