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GRB2 and AXL
Data Source:
BioGRID
(affinity chromatography technology, pull down, far western blotting)
HPRD
(in vitro, in vivo)
GRB2
AXL
Description
growth factor receptor bound protein 2
AXL receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endosome
Golgi Apparatus
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Vesicle Membrane
Extracellular Exosome
Grb2-EGFR Complex
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Actin Cytoskeleton
Intracellular Membrane-bounded Organelle
Receptor Complex
Host Cell Surface
Extracellular Exosome
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Epidermal Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Insulin Receptor Substrate Binding
Protein-containing Complex Binding
Ephrin Receptor Binding
Virus Receptor Activity
Phosphatidylserine Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Myosin Heavy Chain Binding
Phosphatidylinositol 3-kinase Binding
Biological Process
MAPK Cascade
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Axon Guidance
Aging
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Positive Regulation Of Actin Filament Polymerization
T Cell Costimulation
Actin Cytoskeleton Reorganization
Receptor Internalization
Entry Of Bacterium Into Host Cell
Interleukin-15-mediated Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of MAPK Cascade
Positive Regulation Of Ras Protein Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Anatomical Structure Formation Involved In Morphogenesis
Leukocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Branching Involved In Labyrinthine Layer Morphogenesis
Membrane Organization
Cellular Response To Ionizing Radiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Neuron Migration
Natural Killer Cell Differentiation
Positive Regulation Of Cytokine-mediated Signaling Pathway
Blood Vessel Remodeling
Phagocytosis
Inflammatory Response
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Spermatogenesis
Nervous System Development
Cell Migration
Peptidyl-tyrosine Phosphorylation
Forebrain Cell Migration
Platelet Activation
Animal Organ Regeneration
Cellular Response To Extracellular Stimulus
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Differentiation
Secretion By Cell
Positive Regulation Of Kinase Activity
Erythrocyte Homeostasis
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Interferon-alpha
Ovulation Cycle
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Viral Entry Into Host Cell
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell Maturation
Positive Regulation Of Pinocytosis
Negative Regulation Of Lymphocyte Activation
Positive Regulation Of Protein Kinase B Signaling
Vagina Development
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Dendritic Cell Differentiation
Neutrophil Clearance
Positive Regulation Of Viral Life Cycle
Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways
Interleukin-15 signaling
Interleukin-15 signaling
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
VEGFA-VEGFR2 Pathway
Drugs
Pegademase
4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Fostamatinib
Gilteritinib
Diseases
GWAS
Deep white matter hyperintensities (
32517579
)
Multiple sclerosis (
31604244
)
Systemic lupus erythematosus (
29848360
26502338
28714469
)
Systemic sclerosis (
31672989
)
Triglyceride levels (
32203549
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
HDL cholesterol (
31170924
)
Heel bone mineral density (
30598549
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Triglyceride levels (
32203549
32154731
)
Interacting Genes
399 interacting genes:
A2M
ABI3
ABI3BP
ABL1
ABL2
ACAP1
ADA
ADAM12
ADAM15
ADRB1
ADRB2
AEBP1
AGR2
AGT
AHSG
AJUBA
ALAS2
ALOX5
AMBP
ANKRD13A
ANKRD23
ANXA2
AP4S1
APCS
APOH
APP
AR
ARHGAP17
ARHGAP32
ARHGAP35
ARID5A
ASAP1
ASAP2
AUNIP
AXL
B2M
BCAR1
BCL2A1
BCR
BLNK
BPGM
BTG1
C1orf94
C21orf58
C21orf91
CALD1
CASC3
CASP2
CBL
CBLB
CBLC
CCDC28B
CCL5
CD164
CD19
CD22
CD247
CD28
CD2AP
CD72
CDC42
CDKN1B
CFH
CHRM4
CHRND
CKS2
CLNK
CLU
COPB1
COX6A1
CPSF7
CRBN
CRK
CRKL
CSF1R
CSF3R
CSN2
CTTN
CUTA
DAB2
DAG1
DCTN1
DCTN2
DDIT4L
DDX17
DLGAP1
DNAJA3
DNAJB11
DNM1
DNM2
DOCK4
DPPA4
DRD3
DRD4
DTX1
DTX3
DVL2
E2F2
ECHS1
EFHC2
EGF
EGFR
ELK1
ENO1
EP300
EPHA2
EPHB1
EPHB2
EPHB6
EPOR
EPS15
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESD
ESR1
ETV6
FABP1
FASLG
FCGR2A
FCGR2B
FGFR1
FGFR3
FH
FHOD1
FLT1
FLT3
FLT4
FN1
FRS2
FRS3
FTH1
FTL
FYN
GAB1
GAB2
GAB3
GAREM1
GC
GGN
GHR
GIT1
GPANK1
GRAP2
GRB7
GSTK1
H1-0
HCLS1
HELZ
HIPK3
HNRNPC
HNRNPK
HOMEZ
HP
HRAS
HSPA5
HTT
IK
IKZF3
IL2RB
INCA1
INPP5D
IRS1
IRS2
IRS4
ITGA2B
ITGA6
ITGB4
ITIH4
ITK
JAK1
JAK2
KDR
KHDRBS1
KHDRBS2
KIAA0408
KIAA1549L
KIF3A
KIT
KPNA2
KPRP
KRT8
LAT
LAT2
LAX1
LCP2
LIME1
LMO2
LNX1
LNX2
LY6G6F
LZTS2
MAP1A
MAP2
MAP4K1
MAP4K3
MAP4K5
MAPK1
MAPK12
MAPK14
MAPK9
MAPT
MED19
MED28
MEI4
MERTK
MET
METTL27
MIA2
MICAL1
MLXIPL
MS4A2
MSI2
MST1R
MT-ATP8
MT-ND4
MTA1
MTA3
MUC1
MYG1
MYH11
MYH9
MYO18A
MYOZ1
NADK
NAP1L5
NCKIPSD
NCL
NEU3
NFYB
NGFR
NIF3L1
NKD2
NPM1
NTRK1
NUTM2F
OCRL
OLIG1
PACRGL
PAG1
PAK1
PAK2
PAK4
PBXIP1
PCDHB5
PDCD6IP
PDE4D
PDE6G
PDGFRB
PHACTR4
PHC2
PHETA1
PIK3AP1
PIK3C2B
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLEKHA7
PNMA5
PNRC1
POLR1D
POLR2A
POMP
PON2
PPP3CA
PRAP1
PRKAB1
PRKAR1A
PRNP
PRR22
PRR5-ARHGAP8
PRRC2A
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN22
PTPN6
PTPRA
PTPRC
PTPRE
PXN
RALGPS1
RAPGEF1
RAPSN
RASA1
RBBP6
RBM33
RBP4
REL
REPS1
REPS2
RET
RHOU
RIF1
RNF10
RNF208
RPS6KA1
SELL
SF3A2
SF3B4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D4A
SH3BP2
SH3D19
SH3KBP1
SHANK3
SHB
SHBG
SHC1
SHC2
SHC3
SHC4
SHKBP1
SIGLEC7
SIT1
SKAP1
SLC1A2
SLX1A
SNRNP200
SNTA1
SOCS1
SOCS7
SOS1
SOS2
SPATA2L
SPRY1
SPRY2
SPTBN1
SRC
SS18
STAMBP
STK32C
STRADB
SYK
SYN1
SYNCRIP
SYNJ1
SYNJ2
SYP
TBC1D3B
TBC1D3G
TCEAL8
TCERG1
TEK
TF
TFG
TLE5
TNFRSF1A
TNK2
TOM1L1
TP53BP2
TP63
TRAT1
TRIB3
TRIM27
TSC2
TSPAN2
TUB
TXK
TYRO3
UBA1
UBA52
UBC
UQCC2
USP53
USP6NL
USP8
VAV1
VAV2
VAV3
VIM
VPS37C
WAS
WASF1
WASF2
WASL
WBP11
WDFY3
WDR1
WDR44
WIPF1
WIPF2
YLPM1
ZAP70
ZBTB12
ZBTB7B
ZMAT1
ZNF341
ZNF474
ZNF620
23 interacting genes:
ADAM10
CBL
EGFR
FBXO25
GAS6
GRB2
IL15RA
IL2RG
LCK
MTDH
NCK2
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTPN11
RANBP9
SHC1
SHC3
SOCS1
SRC
TNS2
TYRO3
Entrez ID
2885
558
HPRD ID
00150
00171
Ensembl ID
ENSG00000177885
ENSG00000167601
Uniprot IDs
B0LPF3
P62993
M0R0W6
P30530
PDB IDs
1AZE
1BM2
1BMB
1CJ1
1FHS
1FYR
1GCQ
1GFC
1GFD
1GHU
1GRI
1IO6
1JYQ
1JYR
1JYU
1QG1
1TZE
1X0N
1ZFP
2AOA
2AOB
2H46
2H5K
2HUW
2VVK
2VWF
2W0Z
3C7I
3IMD
3IMJ
3IN7
3IN8
3KFJ
3MXC
3MXY
3N7Y
3N84
3N8M
3OV1
3OVE
3S8L
3S8N
3S8O
3WA4
4P9V
4P9Z
5CDW
6ICG
6ICH
6SDF
6VK2
6WM1
6WO2
2C5D
4RA0
5U6B
5VXZ
Enriched GO Terms of Interacting Partners
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