FFAR1 and GNAQ

Data Source:
HPRD (in vivo)

		FFAR1	GNAQ
Description		free fatty acid receptor 1	G protein subunit alpha q
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Lipid Binding Bioactive Lipid Receptor Activity	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Insulin Secretion Positive Regulation Of Insulin Secretion Negative Regulation Of Interleukin-1 Beta Production Glucose Homeostasis Positive Regulation Of Calcium Ion Transport Response To Fatty Acid	Action Potential Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Positive Regulation Of GTPase Activity Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway
Pathways		Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Free fatty acid receptors	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Icosapent
Diseases
GWAS			Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		2 interacting genes: GNAI1 GNAQ	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		2864	2776
HPRD ID		04822	02998
Ensembl ID		ENSG00000126266	ENSG00000156052
Uniprot IDs		O14842	A0A024R240 P50148
PDB IDs		4PHU 5KW2 5TZR 5TZY	6VU5
Enriched GO Terms of Interacting Partners?
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