CCDC141 and HOMER3

Data Source:
BioGRID (two hybrid)

		CCDC141	HOMER3
Description		coiled-coil domain containing 141	homer scaffold protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Neuron Projection	Cellular_component Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite
	Molecular Function	Protein Binding	Protein Binding G Protein-coupled Glutamate Receptor Binding Identical Protein Binding
	Biological Process	Cerebral Cortex Radially Oriented Cell Migration Centrosome Localization	Protein Targeting G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Blood pressure measurement (cold pressor test) ( 24165912) Diastolic blood pressure ( 28135244 27841878 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 30166351 23583979) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Mucinous adenocarcinoma in colorectal cancer ( 29942513) Number of live births ( 30188897) Number of pregnancies ( 30188897) Objective response to lithium treatment ( 26503763) PR interval ( 32439900) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale) ( 28525603) Pulse pressure ( 30578418) QRS duration ( 30012220) QT interval ( 24952745 29874175) Resting heart rate ( 29769521 27798624) Serum polyunsaturated fatty acid concentration x Mediterranean diet adherence interaction in metabolic syndrome ( 31991592) Smoking cessation ( 30617275)
Interacting Genes		4 interacting genes: DISC1 HOMER3 RRAD TSC22D2	86 interacting genes: ABI1 ABI2 ABI3 APP ARL13B C1orf116 C4orf17 CCDC120 CCDC141 CCDC187 CDC37 CDK18 CEBPB CWF19L2 DVL3 DYNLL1 DYNLL2 EAF1 EFHC1 EIF3D FAM161B FAM90A1 FAT1 FBXO28 FRYL GAS8 GGN GRM5 HOMER1 HOXB5 INCA1 ITPR1 KANK2 KANK4 KDM1A KRTAP19-7 LHX2 LNX1 LRRC7 LSM14B MDM1 MEOX1 MFAP1 MIA3 MOS MSS51 NEBL NTAQ1 OTX2 PALLD PAX6 PAX7 PKN1 PLAAT5 POLI POM121 PPP1R18 PPP1R32 PRCC PRR35 PSMA1 PSMA2 PSMC5 PSORS1C2 RBM14 RBM22 RUNX1T1 RYR1 SAXO1 SCNM1 SDCBP SLAIN1 SMR3B SNRPF SRPK2 TBC1D22B TOX2 TRPC1 USP2 WBP2 WIPF1 ZBTB4 ZNF19 ZNF35 ZNF414 ZNF655
Entrez ID		285025	9454
HPRD ID		08257	07270
Ensembl ID		ENSG00000163492	ENSG00000051128
Uniprot IDs		B8ZZB3 Q6ZP82	Q9NSC5
PDB IDs			2P8V 3CVF
Enriched GO Terms of Interacting Partners?
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