HEXD and TUBB3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HEXD	TUBB3
Description		hexosaminidase D	tubulin beta 3 class III
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicle	Nucleus Cytoplasm Microtubule Lamellipodium Filopodium Axon Dendrite Growth Cone Extracellular Exosome
	Molecular Function	Beta-N-acetylhexosaminidase Activity Hexosaminidase Activity N-acetyl-beta-D-galactosaminidase Activity	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Netrin Receptor Binding
	Biological Process	Carbohydrate Metabolic Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Axon Guidance Netrin-activated Signaling Pathway Dorsal Root Ganglion Development
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs			Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases			Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS			Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)
Interacting Genes		9 interacting genes: ADPRS C7orf25 EEF1D GDPD2 GLRX3 PRKN PSD RILPL2 TUBB3	34 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE
Entrez ID		284004	10381
HPRD ID		08677	04044
Ensembl ID		ENSG00000169660	ENSG00000258947
Uniprot IDs		Q8WVB3	Q13509 Q53G92
PDB IDs			5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL
Enriched GO Terms of Interacting Partners?
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