GPC1 and SLIT2

Data Source:
HPRD (in vitro, in vivo)

		GPC1	SLIT2
Description		glypican 1	slit guidance ligand 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Endosome Golgi Lumen Cytosol Plasma Membrane Cell Surface Extracellular Matrix Intrinsic Component Of Plasma Membrane Lysosomal Lumen Membrane Raft Synapse Anchored Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Copper Ion Binding Fibroblast Growth Factor Binding Laminin Binding	GTPase Inhibitor Activity Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding Protein Homodimerization Activity Laminin-1 Binding Proteoglycan Binding Roundabout Binding
	Biological Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Schwann Cell Differentiation Cell Migration Heparan Sulfate Proteoglycan Catabolic Process Myelin Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Leukocyte Migration Regulation Of Protein Localization To Membrane Positive Regulation Of Skeletal Muscle Cell Differentiation	Ureteric Bud Development Negative Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Leukocyte Chemotaxis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Smooth Muscle Cell Migration Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Corticospinal Neuron Axon Guidance Through Spinal Cord Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Negative Regulation Of GTPase Activity Roundabout Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Branching Morphogenesis Of An Epithelial Tube Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Negative Chemotaxis Induction Of Negative Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Heparin Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Signaling by ROBO receptors Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport	Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125)	Adult body size ( 32376654) Body mass index ( 31453325) Body mass index variance ( 31453325) Early spontaneous preterm birth ( 31194736) Echocardiographic traits ( 17903301) Gestational age at birth (child effect) ( 31194736) Pars orbitalis volume ( 31530798) QRS duration ( 27659466) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		5 interacting genes: APP COL18A1 SLIT1 SLIT2 VEGFA	4 interacting genes: GPC1 ROBO1 ROBO2 UBC
Entrez ID		2817	9353
HPRD ID		02671	04776
Ensembl ID		ENSG00000063660	ENSG00000145147
Uniprot IDs		A0A384NPH9 H7C410 P35052	O94813
PDB IDs		4ACR 4AD7 4BWE 4YWT	2V70 2V9S 2V9T 2WFH
Enriched GO Terms of Interacting Partners?
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