GOT2 and PC

Data Source:
HPRD (in vitro)

		GOT2	PC
Description		glutamic-oxaloacetic transaminase 2	pyruvate carboxylase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface T-tubule Protein-containing Complex Perikaryon Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	RNA Binding L-aspartate:2-oxoglutarate Aminotransferase Activity Phospholipid Binding Kynurenine-oxoglutarate Transaminase Activity Amino Acid Binding Enzyme Binding Pyridoxal Phosphate Binding Identical Protein Binding	Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Female Pregnancy Lactation Cellular Amino Acid Biosynthetic Process Response To Muscle Activity Fatty Acid Transport 4-hydroxyproline Catabolic Process Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Response To Insulin Response To Morphine Response To Ethanol Glyoxylate Metabolic Process L-kynurenine Metabolic Process	Pyruvate Metabolic Process Gluconeogenesis Lipid Metabolic Process Biotin Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Process
Pathways		Degradation of cysteine and homocysteine Glyoxylate metabolism and glycine degradation Gluconeogenesis Aspartate and asparagine metabolism Glutamate and glutamine metabolism	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis
Drugs		Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate	Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal
Diseases			Pyruvate carboxylase deficiency
GWAS		Aortic root size ( 21223598) Aspartate aminotransferase levels ( 29403010) Automobile speeding propensity ( 30643258) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Impulsivity (attentional) ( 30718321) Metabolite levels ( 23823483) QT interval ( 19305408) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 31959995) Uterine fibroid number (single vs multiple) ( 30196971)	Bipolar disorder ( 21926972 31043756) Familial squamous cell lung carcinoma ( 29924316) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528)
Interacting Genes		10 interacting genes: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6	3 interacting genes: GOT1 GOT2 MDH2
Entrez ID		2806	5091
HPRD ID		00684	02032
Ensembl ID		ENSG00000125166	ENSG00000173599
Uniprot IDs		P00505	A0A024R5C5 P11498
PDB IDs		5AX8	3BG3 3BG9
Enriched GO Terms of Interacting Partners?
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