GLE1 and NUP42

Data Source:
BioGRID (x-ray crystallography, biochemical, proximity labelling technology)
HPRD (two hybrid, in vitro)

		GLE1	NUP42
Description		GLE1 RNA export mediator	nucleoporin 42
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GO Annotations	Cellular Component	Extracellular Space Nuclear Envelope Nuclear Pore Nucleolus Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Ciliary Basal Body Nuclear Pore Cytoplasmic Filaments	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Membrane Host Cell
	Molecular Function	Inositol Hexakisphosphate Binding Protein Binding Phospholipid Binding Translation Initiation Factor Binding Identical Protein Binding	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	MRNA Export From Nucleus Regulation Of Translational Initiation Regulation Of Translational Termination Poly(A)+ MRNA Export From Nucleus	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Export From Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases		Lethal arthrogryposis with anterior horn cell disease Lethal congenital contractural syndrome (LCCS)
GWAS		Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		4 interacting genes: KRT10 NUP155 NUP42 UXT	4 interacting genes: APC GLE1 KRT34 NUP214
Entrez ID		2733	11097
HPRD ID		04536	14855
Ensembl ID		ENSG00000119392	ENSG00000136243
Uniprot IDs		B3KMG0 Q53GS7	O15504
PDB IDs		6B4F 6B4I 6B4J	6B4F 6B4I 6B4J
Enriched GO Terms of Interacting Partners?
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