DKK2 and LRP6

Data Source:
HPRD (in vivo)

		DKK2	LRP6
Description		dickkopf WNT signaling pathway inhibitor 2	LDL receptor related protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Synapse Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome
	Molecular Function	Protein Binding Co-receptor Binding Receptor Antagonist Activity	Low-density Lipoprotein Particle Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Coreceptor Activity Wnt-protein Binding Kinase Inhibitor Activity Toxin Transmembrane Transporter Activity Apolipoprotein Binding Identical Protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Multicellular Organism Development Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signaling Receptor Activity	Neural Tube Closure Negative Regulation Of Protein Phosphorylation Pericardium Morphogenesis Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Embryonic Pattern Specification Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Cerebellum Morphogenesis Thalamus Development Cerebral Cortex Development Regulation Of Ossification Embryonic Limb Morphogenesis Midbrain Development Midbrain-hindbrain Boundary Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process External Genitalia Morphogenesis Odontogenesis Of Dentin-containing Tooth Response To Peptide Hormone Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Embryonic Camera-type Eye Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Convergent Extension Embryonic Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Face Morphogenesis Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Trachea Cartilage Morphogenesis Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Protein Localization To Plasma Membrane Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Receptor-mediated Endocytosis Involved In Cholesterol Transport Wnt Signaling Pathway Involved In Somitogenesis Axis Elongation Involved In Somitogenesis Cell-cell Adhesion Toxin Transport Beta-catenin Destruction Complex Disassembly Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Male-pattern baldness ( 27182965 28196072) Resting-state electroencephalogram vigilance ( 29703947) Telomere length ( 24478790)	Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Coronary artery calcification ( 23870195) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tandem gait ( 26219847)
Interacting Genes		2 interacting genes: KRTAP10-6 LRP6	17 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 CKLF DKK1 DKK2 FZD5 FZD8 GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A
Entrez ID		27123	4040
HPRD ID		05658	04617
Ensembl ID		ENSG00000155011	ENSG00000070018
Uniprot IDs		Q9UBU2	O75581
PDB IDs			3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16 6L6R
Enriched GO Terms of Interacting Partners?
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