BBC3 and NDUFAB1

Data Source:
BioGRID (two hybrid)

		BBC3	NDUFAB1
Description		BCL2 binding component 3	NADH:ubiquinone oxidoreductase subunit AB1
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GO Annotations	Cellular Component	Mitochondrion Lysosome	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Mitochondrial Large Ribosomal Subunit Mitochondrial Membrane
	Molecular Function	Protein Binding ATPase Binding	Acyl Binding Acyl Carrier Activity Fatty Acid Binding Calcium Ion Binding Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Biosynthetic Process Protein Lipoylation Mitochondrial Respiratory Chain Complex I Assembly
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes	Glyoxylate metabolism and glycine degradation Respiratory electron transport Complex I biogenesis Mitochondrial Fatty Acid Beta-Oxidation
Drugs			NADH
Diseases
GWAS		Monocyte count ( 27863252) White blood cell count ( 32888494)	Bipolar disorder ( 17554300)
Interacting Genes		14 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 FHL5 HGS HSD17B13 MCL1 MYPOP NDUFAB1 UBASH3B WDR5 ZNF438	35 interacting genes: ACTN3 BBC3 BEX5 CCDC24 CNTF EIF3B ERBB3 FEM1A FHL3 FNDC3B HINFP KCTD9 LMO2 LNX1 MBLAC1 MORN3 MRPL23 NOXA1 NRF1 NT5C3A NTAQ1 OIP5 POP5 PPP1R16A PSMC3 RBM18 SLIRP SMYD3 THAP1 TLX3 TOX2 VAC14 ZNF19 ZNF410 ZNF829
Entrez ID		27113	4706
HPRD ID		16165	11951
Ensembl ID		ENSG00000105327	ENSG00000004779
Uniprot IDs		Q96PG8 Q9BXH1	O14561
PDB IDs		2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8 6TQP	2DNW 5OOL 5OOM 5XTB 5XTC 5XTD 5XTH 5XTI 6ODD
Enriched GO Terms of Interacting Partners?
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