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CACYBP and SIAH2
Data Source:
HPRD
(in vitro, two hybrid)
CACYBP
SIAH2
Description
calcyclin binding protein
siah E3 ubiquitin protein ligase 2
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope Lumen
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Beta-catenin Destruction Complex
Neuron Projection
Cell Body
Extracellular Exosome
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Neuron Projection
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Tubulin Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Protein Homodimerization Activity
S100 Protein Binding
Transcription Corepressor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Activity
Biological Process
Heart Development
Aging
Positive Regulation Of DNA Replication
Cardiac Muscle Cell Differentiation
Response To Growth Hormone
Negative Regulation Of Cell Death
Cellular Response To Calcium Ion
Cellular Response To Leukemia Inhibitory Factor
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Small GTPase Mediated Signal Transduction
Multicellular Organism Development
Protein Deubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Rhythmic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Netrin-activated Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Netrin-1 signaling
Ub-specific processing proteases
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
BRCA1/2-negative high-risk breast cancer (
30323354
)
Breast cancer (
22951594
31757997
)
Interacting Genes
20 interacting genes:
BEX3
CCR2
CD8A
ERBB2
FBXO7
HSP90AA1
HSP90B1
MAPK1
NPM1
PEA15
PINX1
PRKCA
S100A1
S100A12
S100A6
S100B
S100P
SIAH1
SIAH2
SKP1
43 interacting genes:
AFF1
AKR1C3
ATN1
CACYBP
CCBE1
CHEK2
DCC
DYRK2
EEF1D
EGLN3
HIPK2
HIPK3
MYD88
NRF1
OPRM1
PEG10
PEG3
PIAS2
PIAS3
PML
POU2AF1
PSMD4
RBBP8
SETD2
SNCA
SNCAIP
SPRY2
STAT3
SYP
TINF2
TP53BP2
TPX2
TRAF2
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2L6
UBE2N
UBE2V2
USP13
USP19
VAV1
Entrez ID
27101
6478
HPRD ID
07316
03737
Ensembl ID
ENSG00000116161
ENSG00000181788
Uniprot IDs
A0A024R904
Q9HB71
O43255
PDB IDs
1X5M
2A25
2A26
5H9M
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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