TRAPPC3 and CDC45

Data Source:
BioGRID (two hybrid)

		TRAPPC3	CDC45
Description		trafficking protein particle complex subunit 3	cell division cycle 45
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol TRAPP Complex Cis-Golgi Network Membrane	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body
	Molecular Function	Protein Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport COPII Vesicle Coating	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs		Palmitic Acid Myristic acid S-palmitoyl-L-cysteine
Diseases
GWAS		Intraocular pressure ( 30054594)	Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		10 interacting genes: APP CDC45 LIG4 PLEKHF2 TRAPPC1 TRAPPC2 TRAPPC2B TRAPPC2L TRAPPC5 TRAPPC6A	25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1
Entrez ID		27095	8318
HPRD ID		11644	09145
Ensembl ID		ENSG00000054116	ENSG00000093009
Uniprot IDs		A0A087WWM0 A0A087WYS5 O43617	O75419
PDB IDs		1SZ7 2C0J 2CFH 3KXC	5DGO 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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