GJB5 and MYL2

Data Source:
BioGRID (two hybrid)

		GJB5	MYL2
Description		gap junction protein beta 5	myosin light chain 2
Image		No pdb structure
GO Annotations	Cellular Component	Connexin Complex Integral Component Of Membrane	Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril
	Molecular Function	Gap Junction Channel Activity Protein Binding	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding
	Biological Process	Cell-cell Signaling Epidermis Development Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Morphogenesis Epididymis Development	Regulation Of The Force Of Heart Contraction Regulation Of Striated Muscle Contraction Heart Development Muscle Filament Sliding Negative Regulation Of Cell Growth Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Positive Regulation Of The Force Of Heart Contraction
Pathways		Gap junction assembly	Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS		Narcolepsy ( 23459209) Sleep duration (short sleep) ( 30846698) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Visceral adipose tissue adjusted for BMI ( 22589738)	Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Alcohol consumption (max-drinks) ( 29460428) Body mass index ( 24861553) Coffee consumption ( 29367735) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) Gout ( 25646370) HDL cholesterol ( 21909109) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 30718733) Metabolic syndrome ( 25705158) Metabolic syndrome (multivariate analysis) ( 29632305) Neutrophil count ( 29403010) Serum uric acid levels ( 32514006) Urate levels ( 31578528) White blood cell count ( 29403010)
Interacting Genes		44 interacting genes: APOL2 APOL3 AQP1 C1GALT1 C4orf3 COMT CTXN3 CYB5B ERG28 FAM3C GSK3B IGFBP5 JAGN1 LMNA LPAR3 LRP10 MED1 MIP MS4A13 MYL2 NAPB PCGF2 PGAP2 PLPP4 PLPP6 PNLIPRP1 RPRM RTP2 SEC22A SEC22B SERP1 SLC30A2 SLC38A7 SLC41A1 SLC41A2 SMIM1 TM4SF4 TMEM128 TMEM60 TMEM86A TMEM97 TRIM2 TSPO2 VSTM1	12 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529
Entrez ID		2709	4633
HPRD ID		06840	01181
Ensembl ID		ENSG00000189280	ENSG00000111245
Uniprot IDs		A0A654IE64 O95377	P10916 Q6IB42
PDB IDs			5TBY
Enriched GO Terms of Interacting Partners?
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