ABL2 and FBXO38

Data Source:
BioGRID (two hybrid)

		ABL2	FBXO38
Description		ABL proto-oncogene 2, non-receptor tyrosine kinase	F-box protein 38
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Actin Cytoskeleton	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding	Protein Binding
	Biological Process	Cellular Protein Modification Process Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Positive Regulation Of Oxidoreductase Activity Cellular Response To Retinoic Acid Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization	Adaptive Immune Response Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Neuron Projection Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Negative regulation of FLT3
Drugs		ATP Dasatinib XL228 K-00546 Fostamatinib
Diseases
GWAS		IgE grass sensitization ( 22036096)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Lung function (FEV1/FVC) ( 31453325) Lung function (FEV1/FVC) variance ( 31453325) Mean reticulocyte volume ( 32888494) Periodontal microbiota ( 22699663) Zinc levels ( 26025379)
Interacting Genes		34 interacting genes: ABI2 ABL1 AR BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1	8 interacting genes: ABL2 APP CREBBP KLF7 PPM1G RING1 SOX30 SUMO2
Entrez ID		27	81545
HPRD ID		01259	09775
Ensembl ID		ENSG00000143322	ENSG00000145868
Uniprot IDs		P42684	Q6AZE0 Q6PIJ6
PDB IDs		2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?
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