AMFR and CNOT1

Data Source:
BioGRID (affinity chromatography technology)

		AMFR	CNOT1
Description		autocrine motility factor receptor	CCR4-NOT transcription complex subunit 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	P-body Extracellular Space Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding
	Biological Process	Protein Polyubiquitination Protein Folding Ubiquitin-dependent Protein Catabolic Process Signal Transduction Aging Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)	Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) HDL cholesterol levels ( 32203549) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) PR interval ( 32439900) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 22726844 19305408 29874175) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		28 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 SOD1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	11 interacting genes: CDC42 CNOT2 CNOT3 CNOT4 CNOT8 DDX6 NANOS3 PPARG RARA RXRA THRB
Entrez ID		267	23019
HPRD ID		09130	11999
Ensembl ID		ENSG00000159461	ENSG00000125107
Uniprot IDs		A0A024R6R5 Q9UKV5	A5YKK6
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD	4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA
Enriched GO Terms of Interacting Partners?
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