MSTN and FSTL3

Data Source:
HPRD (in vivo, in vitro)

		MSTN	FSTL3
Description		myostatin	follistatin like 3
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Nucleus Nucleoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Neuron Projection Terminus
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity	Fibronectin Binding Protein Binding Activin Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Response To Heat Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Negative Regulation Of Kinase Activity Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation	Ossification Kidney Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Male Gonad Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Lung Development Adrenal Gland Development Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Metal Ion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Pathways		FOXO-mediated transcription of cell cycle genes	Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		MYO-029
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Nickel levels ( 26025379)
Interacting Genes		6 interacting genes: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2	5 interacting genes: ADAM12 FN1 INHBA MSTN SMAD4
Entrez ID		2660	10272
HPRD ID		03474	05632
Ensembl ID		ENSG00000138379	ENSG00000070404
Uniprot IDs		O14793 Q53S46	A0A024R1Y8 O95633
PDB IDs		5F3B 5F3H 5NTU 5NXS 6UMX	2KCX 3B4V 3SEK
Enriched GO Terms of Interacting Partners?
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