AGO1 and DCP1A

Data Source:
HPRD (in vivo)

		AGO1	DCP1A
Description		argonaute RISC component 1	decapping mRNA 1A
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Polysome RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex Ribonucleoprotein Complex	P-body Nucleus Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Endoribonuclease Activity Protein Binding MiRNA Binding	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Enzyme Regulator Activity Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Wnt Signaling Pathway, Calcium Modulating Pathway RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Angiogenesis Pre-miRNA Processing Post-transcriptional Gene Silencing By RNA Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Silencing By MiRNA RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In Gene Silencing By SiRNA	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Protein Localization To Cytoplasmic Stress Granule
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) PR interval ( 32439900) Refractive error ( 32231278) Spontaneous preterm birth (preterm delivery) ( 25599974)
Interacting Genes		8 interacting genes: AGO2 APP DCP1A DCP2 DICER1 KHDRBS1 PRNP RELA	16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG
Entrez ID		26523	55802
HPRD ID		06942	06113
Ensembl ID		ENSG00000092847	ENSG00000272886
Uniprot IDs		A0A6I8PTZ8 B2RAD8 B3KME0 Q5TA58 Q9UL18	Q9NPI6
PDB IDs		1SI2 1SI3 4KRE 4KRF 4KXT 5W6V	2WX3 4B6H
Enriched GO Terms of Interacting Partners?
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