GCH1 and AHSA1

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid)

		GCH1	AHSA1
Description		GTP cyclohydrolase 1	activator of HSP90 ATPase activity 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding	ATPase Activator Activity Protein Binding Cadherin Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals	Protein Folding Viral Process Positive Regulation Of ATPase Activity
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanine
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)
Interacting Genes		15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ	8 interacting genes: AKT1 APP CLCN1 EGFR FKBP4 GCH1 HSP90AA1 PTGES3
Entrez ID		2643	10598
HPRD ID		02573	09768
Ensembl ID		ENSG00000131979	ENSG00000100591
Uniprot IDs		A0A024R642 P30793 Q8IZH9	G3V438 O95433
PDB IDs		1FB1	1X53
Enriched GO Terms of Interacting Partners?
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