GBP3 and LRRC8B

Data Source:
BioGRID (affinity chromatography technology)

		GBP3	LRRC8B
Description		guanylate binding protein 3	leucine rich repeat containing 8 VRAC subunit B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Ion Channel Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Homodimerization Activity	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Defense Response To Virus Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Inorganic Anion Transport Transmembrane Transport Anion Transmembrane Transport
Pathways		Interferon gamma signaling	Miscellaneous transport and binding events
Drugs
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Carotid intima media thickness ( 26343869)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)
Interacting Genes		1 interacting genes: MAP4K4
Entrez ID		2635	23507
HPRD ID		02683	18145
Ensembl ID		ENSG00000117226	ENSG00000197147
Uniprot IDs		Q9H0R5	A0A384N5V6 Q6P9F7
PDB IDs
Enriched GO Terms of Interacting Partners?
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