BLOC1S6 and SEMA6D

Data Source:
BioGRID (biochemical)

		BLOC1S6	SEMA6D
Description		biogenesis of lysosomal organelles complex 1 subunit 6	semaphorin 6D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extrinsic Component Of Membrane Transport Vesicle BLOC-1 Complex SNARE Complex Presynapse Axon Cytoplasm	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Syntaxin Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding	Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Anterograde Axonal Transport Synaptic Vesicle Docking Neuron Projection Development Melanosome Transport Melanosome Organization Endosome To Melanosome Transport Intracellular Transport Anterograde Synaptic Vesicle Transport Positive Regulation Of Pigment Cell Differentiation	Neural Crest Cell Migration Axon Guidance Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Migration Ventricular System Development Positive Regulation Of Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis	Other semaphorin interactions
Drugs
Diseases
GWAS			Adult body size ( 32376654) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Antisaccade task score ( 31596458) Attention deficit hyperactivity disorder ( 29325848) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Attention deficit hyperactivity disorder or intracranial volume (pleiotropy) ( 30818988) Attention deficit hyperactivity disorder or putamen volume (pleiotropy) ( 30818988) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Carotid plaque burden (smoking interaction) ( 24954085) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcification ( 23870195) Cuneus cortex volume ( 31530798) Diisocyanate-induced asthma ( 25918132) Eating disorders ( 22911880) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hair greying ( 26926045) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28008999) Lack of perseverance ( 30718321) Lung cancer ( 28604730) Lung function (FVC) ( 30061609) Neurociticism ( 29500382) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Oily fish consumption ( 32066663) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Pericalcarine cortex volume ( 31530798) Phoneme awareness ( 30741946) Pork consumption ( 32066663) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to radiotherapy in cancer (late toxicity) ( 24785509) Restless legs syndrome ( 29029846) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28008999)
Interacting Genes		49 interacting genes: ABI2 AGGF1 ANK1 APP BLOC1S1 BLOC1S2 BLOC1S4 C4orf46 CCDC136 CCDC22 CCHCR1 CCR2 CDK5R1 CEP44 CORO6 DCTN2 DTNBP1 EPS8 EXOC8 HAUS1 IFT20 INSYN1 KRT13 KRT72 LURAP1 MED21 MLPH NDC80 NDN NTAQ1 NUP62 OLFM2 PLEKHA5 PLEKHF2 RABGEF1 RINT1 SKA1 SLC4A1 SMN1 SMN2 SNAPIN STX11 STX12 STX1A SYCE3 TPM1 TPM3 TRAK1 WASHC3	1 interacting genes: PLXNA1
Entrez ID		26258	80031
HPRD ID		16055	10221
Ensembl ID		ENSG00000104164	ENSG00000137872
Uniprot IDs		B3KY40 H3BST1 Q9UL45	A0A185QE25 Q8NFY4
PDB IDs
Enriched GO Terms of Interacting Partners?
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