STAP1 and RETREG3

Data Source:
BioGRID (two hybrid, two hybrid)

		STAP1	RETREG3
Description		signal transducing adaptor family member 1	reticulophagy regulator family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Protein-containing Complex Intracellular Membrane-bounded Organelle	Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Signaling Adaptor Activity	Protein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Phosphorylation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Cellular Response To Lipopolysaccharide Negative Regulation Of Ruffle Assembly Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Activation Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Actin Cytoskeleton Reorganization	Positive Regulation Of Neuron Projection Development Reticulophagy
Pathways
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		14 interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GAB1 GRIPAP1 KIT MET PTK2B RETREG3 SH3KBP1 TEC URI1	109 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARL6IP1 ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 C4orf3 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 IFITM3 JAGN1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 REEP6 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6
Entrez ID		26228	162427
HPRD ID		16053	14108
Ensembl ID		ENSG00000035720	ENSG00000141699
Uniprot IDs		A0A024RD91 Q9ULZ2	K7EQI9 Q86VR2
PDB IDs		1X1F 3MAZ
Enriched GO Terms of Interacting Partners?
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