CHTOP and SMN2

Data Source:
BioGRID (two hybrid)

		CHTOP	SMN2
Description		chromatin target of PRMT1	survival of motor neuron 2, centromeric
Image		No pdb structure
GO Annotations	Cellular Component	Transcription Export Complex Nucleoplasm Nucleolus Nuclear Speck Cytoplasmic Ribonucleoprotein Granule	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Perikaryon Gemini Of Coiled Bodies
	Molecular Function	RNA Binding Protein Binding Methyl-CpG Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	In Utero Embryonic Development RNA Export From Nucleus MRNA Export From Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Histone Methylation MRNA 3'-end Processing Positive Regulation Of ATPase Activity Positive Regulation Of Helicase Activity	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Nervous System Development Import Into Nucleus
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	snRNP Assembly
Drugs			Nusinersen
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		12 interacting genes: APOBEC3C APP DDX39A DDX39B ERH KHDRBS2 PHLDB3 RBM3 SMN1 SMN2 SNRPA SRPK2	36 interacting genes: BLOC1S6 BYSL CHTOP DDX20 DHX9 EHHADH FAM9B FBL FNDC11 GAR1 GEMIN2 HNRNPUL1 IQUB KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 MAGED1 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNU13 SPANXN2 TIAL1 USP9X VPS28
Entrez ID		26097	6607
HPRD ID		13163	09036
Ensembl ID		ENSG00000160679	ENSG00000205571
Uniprot IDs		A0A087X1B7 Q9Y3Y2	B4DP61 E7EQZ4 Q16637
PDB IDs			1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU
Enriched GO Terms of Interacting Partners?
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