ZNF451 and OPLAH

Data Source:
BioGRID (two hybrid)

		ZNF451	OPLAH
Description		zinc finger protein 451	5-oxoprolinase, ATP-hydrolysing
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus PML Body	Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Metal Ion Binding SUMO Ligase Activity	Protein Binding ATP Binding 5-oxoprolinase (ATP-hydrolyzing) Activity Identical Protein Binding
	Biological Process	Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Histone H3-K9 Acetylation	Glutathione Metabolic Process Glutathione Biosynthetic Process
Pathways			Glutathione synthesis and recycling Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Drugs			Glutamic acid
Diseases
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood metabolite levels ( 24816252) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Serum metabolite levels ( 23093944)
Interacting Genes		33 interacting genes: AR CALCOCO2 CDC5L CDCA4 CPTP CREB1 CREBBP FAM118A FXR2 HTT JMJD6 KDM1A KLHL40 LZTR1 MID2 OPLAH PCBD1 PIAS1 PIAS2 PIK3R3 PML PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUMO2 SUV39H1 UBC UBE2I ZNF467	4 interacting genes: GK POU6F2 TPK1 ZNF451
Entrez ID		26036	26873
HPRD ID		10332	14880
Ensembl ID		ENSG00000112200	ENSG00000178814
Uniprot IDs		B4DYS2 Q96JY2 Q9Y4E5	O14841
PDB IDs		5D2M
Enriched GO Terms of Interacting Partners?
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