NECTIN3 and NECTIN2

Data Source:
HPRD (in vitro)

		NECTIN3	NECTIN2
Description		nectin cell adhesion molecule 3	nectin cell adhesion molecule 2
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Axon Dendrite Apical Junction Complex Cell-cell Contact Zone Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Apical Junction Complex Cell-cell Contact Zone Extracellular Exosome
	Molecular Function	Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Spermatid Development Fertilization Adherens Junction Organization Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Plasma Membrane Protein Localization To Cell Junction	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS		Feeling hurt ( 29500382)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		22 interacting genes: AFDN CYSRT1 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-1 KRTAP4-2 KRTAP5-11 KRTAP5-9 KRTAP9-3 NBPF19 NECTIN1 NECTIN2 NOTCH2NLA OTX1 PARD3 PVR RGS20 TIGIT	36 interacting genes: AFDN ATP5MF CD226 CYSRT1 DUS2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP5-9 LCE1C LCE2B LCE2C LCE5A LYRM4 MAPK6 MDFI MEOX2 NBPF19 NECTIN3 NECTIN4 NOTCH2NLA NR4A3 P4HB PICK1 RGS20 SIAH1 TCF4 TGM1 TIGIT USP53
Entrez ID		25945	5819
HPRD ID		08454	02879
Ensembl ID		ENSG00000177707	ENSG00000130202
Uniprot IDs		Q9NQS3	Q92692
PDB IDs		4FOM	3R0N 4DFH 4DFI 4HZA 5V52
Enriched GO Terms of Interacting Partners?
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