WWTR1 and C1orf74

Data Source:
BioGRID (two hybrid)

		WWTR1	C1orf74
Description		WW domain containing transcription regulator 1	chromosome 1 open reading frame 74
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Nuclear Body
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus
Pathways		Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Height ( 31562340) Polycystic ovary syndrome ( 32289280) Preeclampsia ( 23551011)	Alopecia areata ( 25608926)
Interacting Genes		22 interacting genes: C1orf74 DAPK1 IL16 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PPP1CA RTN4IP1 RUNX1 SLC9A3R2 SUMO3 TCP11L1 TEAD1 TEAD2 TEAD3 TEAD4 WBP2 YWHAE YWHAG YWHAZ	6 interacting genes: C22orf23 IGFBP6 MBD3L1 REL TEKT1 WWTR1
Entrez ID		25937	148304
HPRD ID		09580	08682
Ensembl ID		ENSG00000018408	ENSG00000162757
Uniprot IDs		Q9GZV5	A0A0A8K8E6 Q96LT6
PDB IDs		5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX
Enriched GO Terms of Interacting Partners?
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