ATL3 and POLA2

Data Source:
BioGRID (two hybrid)

		ATL3	POLA2
Description		atlastin GTPase 3	DNA polymerase alpha 2, accessory subunit
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding Identical Protein Binding	Molecular_function DNA Binding Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Protein Homooligomerization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS			Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		1 interacting genes: APP	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		25923	23649
HPRD ID		13170	10160
Ensembl ID		ENSG00000184743	ENSG00000014138
Uniprot IDs		B4DXC4 F5H6I7 Q6DD88	Q14181
PDB IDs		5VGR	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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