RAB26 and RIMS1

Data Source:
HPRD (in vivo)

		RAB26	RIMS1
Description		RAB26, member RAS oncogene family	regulating synaptic membrane exocytosis 1
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GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Secretory Granule Membrane Intrinsic Component Of Plasma Membrane Anchored Component Of Synaptic Vesicle Membrane	Cytosol Plasma Membrane Presynaptic Membrane Cell Projection Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone
	Molecular Function	GTPase Activity Protein Binding GTP Binding GMP Binding	RNA Binding Protein Binding GTPase Regulator Activity Small GTPase Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Regulation Of Exocytosis Exocrine System Development Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission	Intracellular Protein Transport Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Cell Differentiation Regulation Of Membrane Potential Regulated Exocytosis Secretion Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Positive Regulation Of Synaptic Transmission Response To Stimulus Acrosomal Vesicle Exocytosis Membrane Fusion Protein-containing Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		RAB geranylgeranylation	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation
Drugs
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS			Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Chronotype ( 30696823) Cognitive performance ( 20125193) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to mTOR inhibitor (rapamycin) ( 24009623) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 29483656 30285260) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: APP FHL5 GCH1 KRT33B OIP5 RIMS1 UNKL	15 interacting genes: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH
Entrez ID		25837	22999
HPRD ID		05676	09435
Ensembl ID		ENSG00000167964	ENSG00000079841
Uniprot IDs		Q9ULW5	B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5
PDB IDs		2G6B	2CSS
Enriched GO Terms of Interacting Partners?
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