GAD2 and TSPAN33

Data Source:
BioGRID (two hybrid)

		GAD2	TSPAN33
Description		glutamate decarboxylase 2	tetraspanin 33
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Cell Surface Pore Complex Tetraspanin-enriched Microdomain
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding	Protein Binding Enzyme Binding
	Biological Process	Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Biosynthetic Process Response To Drug	Cellular Protein Metabolic Process Pore Complex Assembly Protein Maturation Protein Localization To Plasma Membrane
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling	Amyloid fiber formation
Drugs		Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Lean body mass ( 28552196)	Estimated glomerular filtration rate ( 31015462) Ulcerative colitis ( 23128233)
Interacting Genes		45 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BSND CACNG1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A GAD1 HIGD1C LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TMEM159 TNFRSF10D TSPAN33	27 interacting genes: CHRM2 CISD2 CLDN7 COQ9 DARS2 ERGIC3 FAM209A GAD2 GJA8 GORAB GPR152 GPX8 KCNK5 LHFPL5 LMNA MFF MGST3 MTIF3 NEMP1 PLEKHO1 RELL2 SHISA4 SIT1 SLC35C2 SPINT1 TMEM106C TMEM45B
Entrez ID		2572	340348
HPRD ID		11817	14669
Ensembl ID		ENSG00000136750	ENSG00000158457
Uniprot IDs		Q05329 Q5VZ30	Q86UF1
PDB IDs		1ES0 2OKK
Enriched GO Terms of Interacting Partners?
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