FYB1 and EVL

Data Source:
HPRD (in vivo)

		FYB1	EVL
Description		FYN binding protein 1	Enah/Vasp-like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Protein-containing Complex	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding Protein-containing Complex Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Immune Response Integrin-mediated Signaling Pathway Biological_process T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		15 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC VASP WAS	33 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		2533	51466
HPRD ID		04107	10942
Ensembl ID		ENSG00000082074	ENSG00000196405
Uniprot IDs		O15117	A0A024R6K5 Q9UI08
PDB IDs		1RI9 2GTJ 2GTO
Enriched GO Terms of Interacting Partners?
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