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ACKR1 and CCL2
Data Source:
HPRD
(in vivo, in vitro)
ACKR1
CCL2
Description
atypical chemokine receptor 1 (Duffy blood group)
C-C motif chemokine ligand 2
Image
GO Annotations
Cellular Component
Early Endosome
Plasma Membrane
Integral Component Of Membrane
Recycling Endosome
Extracellular Region
Extracellular Space
Molecular Function
Transmembrane Signaling Receptor Activity
G Protein-coupled Receptor Activity
C-C Chemokine Binding
Signaling Receptor Activity
Protein Kinase Activity
Signaling Receptor Binding
Protein Binding
Chemokine Activity
CCR2 Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Biological Process
Defense Response
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Regulation Of Chemokine Production
Chemokine-mediated Signaling Pathway
MAPK Cascade
Angiogenesis
Monocyte Chemotaxis
Protein Phosphorylation
Chemotaxis
Inflammatory Response
Humoral Immune Response
Cytoskeleton Organization
Cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Shape
Response To Bacterium
Animal Organ Morphogenesis
Viral Genome Replication
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Cellular Homeostasis
Neutrophil Chemotaxis
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Helper T Cell Extravasation
PERK-mediated Unfolded Protein Response
Protein Kinase B Signaling
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Astrocyte Cell Migration
Cellular Response To Fibroblast Growth Factor Stimulus
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of T Cell Activation
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Synaptic Transmission, Glutamatergic
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Calcium Ion Import
Positive Regulation Of NMDA Glutamate Receptor Activity
Negative Regulation Of Vascular Endothelial Cell Proliferation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Apoptotic Cell Clearance
Negative Regulation Of Natural Killer Cell Chemotaxis
Pathways
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
ATF4 activates genes in response to endoplasmic reticulum stress
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Drugs
Mimosine
Danazol
Chondroitin sulfate
Diseases
GWAS
Eotaxin levels (
27989323
)
Growth-regulated protein alpha levels (
27989323
)
Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) (
32047095
)
Monocyte chemoattractant protein-1 levels (
27989323
31217265
)
Neutrophil level response to clozapine in treatment-resistant schizophrenia (
30647433
)
Crohn's disease (
28067908
22412388
21102463
)
Gut microbiota (functional units) (
27694959
)
Hypothyroidism (
22493691
)
Inflammatory bowel disease (
28067908
23128233
)
Interacting Genes
9 interacting genes:
CCL17
CCL2
CCL5
CCL7
CCL8
CXCL1
CXCL5
CXCL8
MTNR1B
28 interacting genes:
ACKR1
ACKR2
ACKR4
CCL11
CCL13
CCL15
CCL26
CCL4L1
CCL5
CCL8
CCR1
CCR10
CCR3
CCR5
CXCL17
CXCL8
CXCL9
MMP1
MMP3
MMP8
PF4
RNF4
SLC16A2
SLC22A1
SLC22A2
TMX2
VCAN
XCL2
Entrez ID
2532
6347
HPRD ID
00192
01149
Ensembl ID
ENSG00000213088
ENSG00000108691
Uniprot IDs
Q16570
Q5Y7A1
Q5Y7A2
P13500
PDB IDs
4NUU
4NUV
1DOK
1DOL
1DOM
1DON
1MCA
1ML0
2BDN
2NZ1
3IFD
4DN4
4R8I
4ZK9
Enriched GO Terms of Interacting Partners
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