HEBP2 and PDCD6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HEBP2	PDCD6
Description		heme binding protein 2	programmed cell death 6
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Azurophil Granule Lumen Extracellular Exosome	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Heme Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Necrotic Cell Death Positive Regulation Of Mitochondrial Membrane Permeability Neutrophil Degranulation Regulation Of Response To Reactive Oxygen Species	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Protein Ubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination
Pathways		Neutrophil degranulation
Drugs			Calcium Zinc Calcium citrate Calcium Phosphate Calcium phosphate dihydrate Zinc acetate
Diseases
GWAS
Interacting Genes		4 interacting genes: LAMTOR5 LRPPRC PDCD6 PLEKHF2	22 interacting genes: ANXA11 ANXA7 BAG4 CDKN2A CPNE1 CPNE2 CPNE4 CUL3 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 PRR19 SEC31A SH3KBP1 TIMM22 VPS37C YWHAQ
Entrez ID		23593	10016
HPRD ID		09316	03035
Ensembl ID		ENSG00000051620	ENSG00000249915
Uniprot IDs		Q5THN1 Q9Y5Z4	A0A024QZ42 A0A087WZ38 O75340 Q53FC3
PDB IDs		3R85 3R8J 3R8K 4AYZ 4B0Y 5GQQ	2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ
Enriched GO Terms of Interacting Partners?
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