FOSB and JUND

Data Source:
HPRD (in vitro)

		FOSB	JUND
Description		FosB proto-oncogene, AP-1 transcription factor subunit	JunD proto-oncogene, AP-1 transcription factor subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Chromatin Nucleoplasm Transcription Regulator Complex Protein-DNA Complex Transcription Factor AP-1 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Nuclear Receptor Binding Enzyme Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Female Pregnancy Response To Mechanical Stimulus Response To Progesterone Cellular Response To Hormone Stimulus Response To Drug Response To Morphine Positive Regulation Of Transcription By RNA Polymerase II Response To Corticosterone Response To CAMP Cellular Response To Calcium Ion	Osteoblast Development Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Aging Circadian Rhythm Response To Light Stimulus Response To Mechanical Stimulus Response To Organic Cyclic Compound Response To Lipopolysaccharide Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Calcium Ion
Pathways		Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription	Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Heel bone mineral density ( 30598549 28869591)	Autoimmune thyroid disease ( 32581359) Bronchodilator response in asthma ( 25562107) Estimated glomerular filtration rate ( 31015462 30604766) Hand grip strength ( 29691431) Systemic lupus erythematosus ( 33536424) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count (monocyte) ( 28158719)
Interacting Genes		28 interacting genes: AGXT ATF2 CENPO CREB5 CYTH4 DNMT3L ENKD1 EP300 FAM222B FAM90A1 FOXP3 GLIS2 JUN JUNB JUND NCK2 NEDD9 PHC2 PHF1 POGZ POU6F2 ROR2 SRA1 TENT5B TLE5 TLX3 VEZF1 ZC3H10	30 interacting genes: ACTR3 ATF3 BATF BCL6 BRCA1 CCND1 COP1 COPS5 DDIT3 EP300 ESR1 FOS FOSB FOSL2 HINFP JDP2 LINC00461 MAPK1 MAPK3 MAPK8 MAPK9 MDM2 MEN1 NFE2L1 NFE2L2 PPARG SLC25A12 SMAD3 SMAD4 TBP
Entrez ID		2354	3727
HPRD ID		01270	01304
Ensembl ID		ENSG00000125740	ENSG00000130522
Uniprot IDs		A0A024R0P6 K7EKC1 P53539	P17535
PDB IDs		5VPA 5VPB 5VPC 5VPD 5VPE 5VPF 6UCI 6UCL 6UCM	3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF
Enriched GO Terms of Interacting Partners?
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