SUZ12 and ARHGAP5

Data Source:
BioGRID (biochemical)

		SUZ12	ARHGAP5
Description		SUZ12 polycomb repressive complex 2 subunit	Rho GTPase activating protein 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific)	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding SH2 Domain Binding
	Biological Process	Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Trimethylation	Cell Adhesion Rho Protein Signal Transduction Mammary Gland Development Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events	Rho GTPase cycle
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Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)	Asthma ( 29273806)
Interacting Genes		17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77	11 interacting genes: ADRB2 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND1 RND2 RND3 SMURF2
Entrez ID		23512	394
HPRD ID		06949	04060
Ensembl ID		ENSG00000178691	ENSG00000100852
Uniprot IDs		J3QQW9 Q15022	Q13017
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3	2EE4 2EE5 5U4V
Enriched GO Terms of Interacting Partners?
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