FNTB and CCDC24

Data Source:
BioGRID (two hybrid)

		FNTB	CCDC24
Description		farnesyltransferase, CAAX box, beta	coiled-coil domain containing 24
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex
	Molecular Function	Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding	Protein Binding
	Biological Process	Protein Phosphopantetheinylation Protein Prenylation Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway	Blastocyst Hatching
Pathways		Inactivation, recovery and regulation of the phototransduction cascade RAS processing
Drugs		AZD3409 Tipifarnib Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Eosinophil counts ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		17 interacting genes: AGXT APOL6 ATPAF2 CCDC24 CENPF FNTA GBP1 HDAC6 HOXC8 HRAS KRAS KRBA1 PTP4A3 RAP2A RRAS2 SMG9 TLX3	35 interacting genes: ADRA2C AKAP8L ANTKMT CDC23 DISC1 FAM166B FNTB GATA1 HYI IKZF3 KRT33B KRT34 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-3 LRP2BP MAGEA6 NDUFAB1 NDUFB7 OIP5 REN RNF31 TCEAL8 TRIM42 TRIP6 TTC23 TTC23L USHBP1 USP54 WWOX ZMYND12
Entrez ID		2342	149473
HPRD ID		00608	14636
Ensembl ID		ENSG00000257365	ENSG00000159214
Uniprot IDs		A0A384MEJ5 P49356	Q8N4L8
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?
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