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FN1 and KPNA2
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
FN1
KPNA2
Description
fibronectin 1
karyopherin subunit alpha 2
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Host Cell
Extrinsic Component Of Postsynaptic Specialization Membrane
Glutamatergic Synapse
Molecular Function
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Protein C-terminus Binding
Heparin Binding
Peptidase Activator Activity
Enzyme Binding
Identical Protein Binding
Proteoglycan Binding
Chaperone Binding
Disordered Domain Specific Binding
RNA Binding
Protein Binding
Nuclear Localization Sequence Binding
Histone Deacetylase Binding
Nuclear Import Signal Receptor Activity
Biological Process
Angiogenesis
Regulation Of Protein Phosphorylation
Platelet Degranulation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptide Cross-linking
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Leukocyte Migration
Biological Process Involved In Interaction With Symbiont
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Regulation Of DNA Recombination
DNA Metabolic Process
NLS-bearing Protein Import Into Nucleus
Modulation By Virus Of Host Cellular Process
Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
Postsynapse To Nucleus Signaling Pathway
Positive Regulation Of Viral Life Cycle
Pathways
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Extracellular matrix organization
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
CaMK IV-mediated phosphorylation of CREB
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Sensing of DNA Double Strand Breaks
Estrogen-dependent gene expression
Drugs
Zinc
Lanoteplase
Ocriplasmin
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Blood protein levels (
28240269
)
Cholesterol, total (
26780889
)
Coronary artery disease (
32469254
29212778
28714974
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
32203549
28334899
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Negative urgency (
30718321
)
Pulse pressure (
28135244
27841878
30578418
)
Systolic blood pressure (
27841878
30578418
)
Total cholesterol levels (
28334899
)
White blood cell count (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Feeling lonely (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Loneliness (
29970889
)
Loneliness (MTAG) (
29970889
)
Refractive error (
32231278
)
Regular attendance at a religious group (
29970889
)
Interacting Genes
105 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COMP
CRP
CTSD
CXCL12
DCN
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HRG
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
SCGB1A1
SDC2
SGCA
SH3GLB1
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TMPRSS6
TNC
TNFRSF11B
TSHR
TTN
UBQLN1
VEGFA
VHL
109 interacting genes:
ACTN1
ACTN4
ANKIB1
AP2B1
APOBEC1
APP
ARL4A
ARL5A
BAG6
BRCA1
BTBD2
CASP2
CCDC107
CDA
CDC42
CDK5RAP3
CHD3
CHEK2
CORO1B
CREB3L3
CREBBP
CSE1L
CSNK1A1
CUL4B
DCPS
DCTN2
DDIT3
EP300
EPB41
FEZ2
FN1
FTH1
GART
GMCL1
GRB2
GTF2IRD1
H1-0
HAP1
HMG20A
HNRNPC
HOMER2
HOMEZ
HSPA4
IFT20
IMMT
INO80E
ITK
JUN
KLC4
KPNB1
KRT18
KRT40
KRT8
LAMB2
LEF1
LZTS2
MAGED1
MAGEH1
MDFI
MLH1
MORC3
MORF4L1
MVP
NECAB2
NFKBIB
NMNAT1
NR3C1
NUP153
NUP50
NUP62
NUTM1
PAX5
PLAG1
PNMA5
PRKD3
PTMA
RAG1
RAN
RANBP2
RBM48
RBPMS
RECQL
RELA
RELB
RGL2
RILP
RNMT
SART3
SERTAD3
SGK1
SLC2A2
SPRY1
SRPK1
SUMO2
TADA2A
TAF3
TAF8
TANK
TBPL2
TP53
TRAF1
TRIM54
TSC22D4
TXNIP
UBR5
USHBP1
ZBTB7B
ZC3H12A
ZNF131
Entrez ID
2335
3838
HPRD ID
00626
02818
Ensembl ID
ENSG00000115414
ENSG00000182481
Uniprot IDs
B7ZLE5
P02751
Q6MZF4
Q6MZM7
Q6N084
Q9UQS6
P52292
PDB IDs
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
6NAJ
1EFX
1QGK
1QGR
3FEX
3FEY
3WPT
4E4V
4WV6
5H43
Enriched GO Terms of Interacting Partners
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