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FLT4 and DUSP19
Data Source:
BioGRID
(two hybrid)
FLT4
DUSP19
Description
fms related receptor tyrosine kinase 4
dual specificity phosphatase 19
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Cytoplasm
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Protein Phosphatase Binding
Protein Homodimerization Activity
Protein Tyrosine Phosphatase Activity
Protein Kinase Inhibitor Activity
MAP-kinase Scaffold Activity
Protein Binding
JUN Kinase Phosphatase Activity
Protein Kinase Activator Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Lymph Vessel Development
Lymphangiogenesis
Sprouting Angiogenesis
Hematopoietic Progenitor Cell Differentiation
Respiratory System Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Endothelial Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Kinase Activity
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Lung Alveolus Development
Blood Vessel Morphogenesis
Regulation Of Blood Vessel Remodeling
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Kinase C Signaling
Negative Regulation Of Protein Kinase Activity
Activation Of Protein Kinase Activity
Peptidyl-tyrosine Dephosphorylation
Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Negative Regulation Of JUN Kinase Activity
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of JNK Cascade
Positive Regulation Of JNK Cascade
Pathways
VEGF binds to VEGFR leading to receptor dimerization
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Sorafenib
Sunitinib
Vatalanib
TG-100801
Denibulin
ABT-869
IMC-1C11
Pazopanib
Axitinib
Regorafenib
Lenvatinib
Nintedanib
Fostamatinib
Selpercatinib
Diseases
Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS
Blood protein levels (
30072576
29875488
)
Platelet distribution width (
32888494
)
Serum folate levels (
29953918
)
Interacting Genes
16 interacting genes:
ATF7IP
DUSP19
ERBB2
GRB2
IKBKG
ITGA5
ITGB1
KDR
LRRK1
NEDD4
PTK2
PTPN11
SHC1
SHC3
VEGFC
VEGFD
20 interacting genes:
ACTB
ALAS1
ALK
EGFR
EPHA2
EPHB6
ERBB2
ERBB3
ERBB4
FLT4
IGF1R
INSR
KDR
LMTK2
MAP2K7
MAP3K5
MAPK9
PTK7
ROR1
ROR2
Entrez ID
2324
142679
HPRD ID
00636
13254
Ensembl ID
ENSG00000037280
ENSG00000162999
Uniprot IDs
P35916
Q8WTR2
PDB IDs
4BSJ
4BSK
3S4E
4D3P
4D3Q
4D3R
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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