FLT3LG and PFN2

Data Source:
HPRD (two hybrid)

		FLT3LG	PFN2
Description		fms related receptor tyrosine kinase 3 ligand	profilin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Integral Component Of Membrane	Cytoplasm Cytoskeleton Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity
	Biological Process	MAPK Cascade Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants	Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			Triglyme Pentaglyme
Diseases
GWAS		Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)	Fish- and plant-related diet ( 32066663)
Interacting Genes		4 interacting genes: FLT3 KITLG KRTAP5-9 PFN2	34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		2323	5217
HPRD ID		02477	01451
Ensembl ID		ENSG00000090554	ENSG00000070087
Uniprot IDs		B7ZLY4 M0QYM9 P49771	P35080
PDB IDs		1ETE 3QS7 3QS9	1D1J
Enriched GO Terms of Interacting Partners?
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