GSE1 and CEP63

Data Source:
BioGRID (two hybrid)

		GSE1	CEP63
Description		Gse1 coiled-coil protein	centrosomal protein 63
Image		No pdb structure
GO Annotations	Cellular Component		Spindle Pole Centrosome Centriole Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cobalt levels ( 26025379) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494 27863252) Triglyceride levels x loop diuretics use interaction ( 31806883) Triglycerides ( 30275531)	Height ( 18391952) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		27 interacting genes: C1orf94 CADPS CARD10 CDC5L CEP63 CEP70 CFAP206 DGCR6 EXOSC6 GOLGA2 LENG8 NUDT18 RALBP1 RBM48 RBPMS RCOR3 RUNX1T1 SRPK2 TEKT4 TFIP11 TNIK TRAF2 TRIM27 TRIP6 TULP3 XRCC6 ZMYND19	66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA TXLNB USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774
Entrez ID		23199	80254
HPRD ID		11066	07826
Ensembl ID		ENSG00000131149	ENSG00000182923
Uniprot IDs		Q14687	Q96MT8
PDB IDs			6CSU 6CSV
Enriched GO Terms of Interacting Partners?
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