FLOT2 and FLOT1

Data Source:
HPRD (in vitro)

		FLOT2	FLOT1
Description		flotillin 2	flotillin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Uropod Endosome Plasma Membrane Caveola Adherens Junction Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Endocytic Vesicle Cortical Actin Cytoskeleton Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Extracellular Exosome	Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Membrane Raft Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Membrane Raft Assembly Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Toll-like Receptor 3 Signaling Pathway Protein Localization To Plasma Membrane Raft Regulation Of Myoblast Differentiation Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Plasma Membrane Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Establishment Of T Cell Polarity	Membrane Raft Assembly Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Axonogenesis Extracellular Matrix Disassembly Positive Regulation Of Protein Binding Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Interferon-beta Production DsRNA Transport Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Rho Protein Signal Transduction Plasma Membrane Raft Assembly Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Neurotransmitter Uptake Positive Regulation Of Cell Adhesion Molecule Production Protein Kinase C Signaling Cellular Response To Exogenous DsRNA Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Protein Localization To Membrane Raft Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules	RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010) Red blood cell count ( 27863252)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) General cognitive ability ( 29844566) Handedness (non-right-handed vs right-handed) ( 31504236) Schizophrenia ( 30285260) Sleep duration ( 25469926) Ulcerative colitis ( 20848476)
Interacting Genes		11 interacting genes: APP CAV1 CAV2 DXO FLOT1 FYN HGS MAGEB4 NMNAT1 SPATA24 UBC	23 interacting genes: APP ARG1 AURKB BANP CAPN10 CBL CCDC102B COX5B FAM90A1 FLOT2 FYN GOLM1 HGS INCENP NGB NME7 PSMD4 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC
Entrez ID		2319	10211
HPRD ID		00580	06105
Ensembl ID		ENSG00000132589	ENSG00000137312
Uniprot IDs		A0A024QZ62 J3QLD9 Q14254 Q6FG43 Q9BTI6	O75955 Q5ST80
PDB IDs
Enriched GO Terms of Interacting Partners?
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