RALY and SKA2

Data Source:
BioGRID (two hybrid)

		RALY	SKA2
Description		RALY heterogeneous nuclear ribonucleoprotein	spindle and kinetochore associated complex subunit 2
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GO Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule
	Molecular Function	Transcription Coregulator Activity RNA Binding Protein Binding	Protein Binding Microtubule Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Cholesterol Homeostasis Regulation Of Nucleic Acid-templated Transcription	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Basal cell carcinoma ( 31174203 27539887) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 22976474) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Estimated glomerular filtration rate ( 31451708) Facial pigmentation ( 25705849) Hair color ( 29662168) HDL cholesterol levels ( 32203549) Idiopathic dilated cardiomyopathy ( 29495422) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Melanoma ( 28212542) Nevus count or cutaneous melanoma ( 32341527) Non-melanoma skin cancer ( 29739929) Red cell distribution width ( 32888494) Red vs. brown/black hair color ( 30531825) Refractive error ( 32231278) Skin colour saturation ( 25963972) Skin sensitivity to sun ( 25963972) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell carcinoma ( 26829030) Type 2 diabetes ( 30297969) Vitiligo ( 27723757) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)	Cognitive function ( 25644384) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)
Interacting Genes		31 interacting genes: BCCIP BYSL CELF1 EXOC7 GTPBP3 HNRNPC HNRNPCL1 HNRNPD HNRNPH1 HNRNPK HSF2BP KHDRBS1 LNX1 MRPL38 MTUS2 PCBP1 PIK3CD PLOD3 QKI RALYL RBPMS2 RPL9 SDCBP SKA2 SPG7 THAP1 TIGD3 WDR62 ZBTB24 ZNF408 ZNF76	6 interacting genes: HMOX2 IFT57 PRKD3 RALY SKA1 SPC24
Entrez ID		22913	348235
HPRD ID		11480	13306
Ensembl ID		ENSG00000125970	ENSG00000182628
Uniprot IDs		Q53GL6 Q9UKM9	J3KSP0 Q8WVK7
PDB IDs		1WF1	4AJ5
Enriched GO Terms of Interacting Partners?
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