CLSTN1 and SLK

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CLSTN1	SLK
Description		calsyntenin 1	STE20 like kinase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Endoplasmic Reticulum Membrane Cell Surface Postsynaptic Membrane Postsynaptic Endosome Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Density Membrane Integral Component Of Spine Apparatus Membrane	Cytoplasm Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Calcium Ion Binding Protein Binding Kinesin Binding X11-like Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Cell Growth Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Synapse Maturation Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	Apoptotic Process Regulation Of Cell Migration Cytoplasmic Microtubule Organization Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Focal Adhesion Assembly
Pathways
Drugs			K-00546 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile Fostamatinib
Diseases
GWAS			Diastolic blood pressure ( 29403010) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Pulse pressure ( 30487518) Systolic blood pressure ( 30487518) Uterine fibroids ( 21460842 31649266)
Interacting Genes		14 interacting genes: APBA2 APBB1 BAHCC1 COL17A1 KIF2A KLC1 KLC2 MCM3AP MDM2 PRNP SETDB1 SLK TOPBP1 TRIP12	3 interacting genes: CASP3 CLSTN1 PDZK1
Entrez ID		22883	9748
HPRD ID		10837	11585
Ensembl ID		ENSG00000171603	ENSG00000065613
Uniprot IDs		B4E3Q1 O94985	Q9H2G2
PDB IDs			2J51 2JFL 2JFM 2UV2 4USF 6HVD
Enriched GO Terms of Interacting Partners?
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