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FKBP4 and ACVR1
Data Source:
HPRD
(in vivo)
FKBP4
ACVR1
Description
FKBP prolyl isomerase 4
activin A receptor type 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Microtubule
Protein-containing Complex
Neuronal Cell Body
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Apical Part Of Cell
Activin Receptor Complex
BMP Receptor Complex
Molecular Function
RNA Binding
Peptidyl-prolyl Cis-trans Isomerase Activity
Protein Binding
FK506 Binding
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Copper-dependent Protein Binding
Tau Protein Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Peptide Hormone Binding
Protein Homodimerization Activity
Cadherin Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Protein Tyrosine Kinase Binding
Biological Process
Protein Peptidyl-prolyl Isomerization
Protein Folding
Copper Ion Transport
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Microtubule Polymerization Or Depolymerization
Negative Regulation Of Microtubule Polymerization
Chaperone-mediated Protein Folding
Regulation Of Cellular Response To Heat
G1/S Transition Of Mitotic Cell Cycle
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Mesoderm Formation
Neural Crest Cell Migration
Acute Inflammatory Response
Embryonic Heart Tube Morphogenesis
Outflow Tract Septum Morphogenesis
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Endocardial Cushion Morphogenesis
Endocardial Cushion Fusion
Atrial Septum Primum Morphogenesis
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Germ Cell Development
Determination Of Left/right Symmetry
Heart Development
Dorsal/ventral Pattern Formation
Negative Regulation Of Signal Transduction
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Ossification
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Negative Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Smooth Muscle Cell Differentiation
Pharyngeal System Development
Pathway-restricted SMAD Protein Phosphorylation
Ventricular Septum Morphogenesis
Cardiac Muscle Cell Fate Commitment
BMP Signaling Pathway Involved In Heart Development
Endocardial Cushion Cell Fate Commitment
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Determination Of Dorsal Identity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
ESR-mediated signaling
Estrogen-dependent gene expression
Potential therapeutics for SARS
Drugs
ATP
Dorsomorphin
Fostamatinib
Diseases
Fibrodysplasia ossificans progressiva (FOP)
GWAS
Apolipoprotein A1 levels (
32203549
)
FEV1 (
30804560
)
Lung function (FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Quantitative traits (
19197348
)
Severe gingival inflammation (
28459102
)
Interacting Genes
26 interacting genes:
ACVR1
AHSA1
ATOX1
CALM1
CSNK2A1
EGFR
ESR1
FES
FKBP1A
GLMN
HSF1
HSP90AA1
HSPA4
IRF4
NR3C1
NR3C2
PHYH
PTPN2
S100A1
S100A2
S100A6
SH3BP4
SMURF2
SNCA
SQSTM1
STIP1
70 interacting genes:
AP2B1
BAMBI
BMP2
BMP6
BMP7
BMPR1A
BMPR2
CDK14
CHN1
CREBBP
DCAF6
DUSP13
ENG
FANCL
FBXO30
FBXO7
FCHO1
FGD6
FKBP4
FNTA
GDF2
GDF5
IGSF1
IKBKB
INHBA
INHBB
INHBC
KLHL35
NEK8
NKIRAS1
NRAS
NUAK2
OTUB1
PAK1
PLEK
PLEKHB1
PLEKHJ1
RAB17
RAB25
RAB33B
RAB3B
RAB6B
RAP2A
RASD2
RASL12
RHEBL1
RHOD
RHOJ
RPS27A
RRAS2
RXRA
SMAD1
SMAD5
SMAD9
SOCS6
STIP1
STX8
TDGF1
TGFBR1
TGFBR2
THRB
TTC17
TTC27
UBA52
UBE2E3
UBXN1
USP39
VDR
VEPH1
WDR61
Entrez ID
2288
90
HPRD ID
11794
00021
Ensembl ID
ENSG00000004478
ENSG00000115170
Uniprot IDs
Q02790
D3DPA4
Q04771
PDB IDs
1N1A
1P5Q
1Q1C
1QZ2
4DRJ
4LAV
4LAW
4LAX
4LAY
4TW8
6RCY
3H9R
3MTF
3OOM
3Q4U
4BGG
4C02
4DYM
5OXG
5OY6
6ACR
6EIX
6GI6
6GIN
6GIP
6I1S
6JUX
6SRH
6SZM
6T6D
6T8N
6TN8
6Z36
6ZGC
7A21
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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