RHOBTB3 and CCNE1

Data Source:
BioGRID (enzymatic study)

		RHOBTB3	CCNE1
Description		Rho related BTB domain containing 3	cyclin E1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Trans-Golgi Network Membrane Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin E1-CDK2 Complex
	Molecular Function	GTPase Activity Protein Binding ATP Binding GTP Binding ATPase Activity Protein Kinase Binding Small GTPase Binding	Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Male Gonad Development Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Retrograde Transport, Endosome To Golgi	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Homologous Chromosome Pairing At Meiosis Wnt Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Mesenchymal Stem Cell Proliferation Regulation Of Cellular Protein Localization
Pathways		Retrograde transport at the Trans-Golgi-Network RHOBTB3 ATPase cycle	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RHOBTB3 ATPase cycle
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS			Adult body size ( 32376654) Bladder cancer ( 24163127 20972438) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 28135244 27841878) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458)
Interacting Genes		17 interacting genes: BHLHE40 CCNE1 CUL3 EFHC2 HGS IHO1 L3MBTL3 PLAGL2 RAB9A RBPMS RBX1 RHOBTB2 TBX15 UBXN11 USP54 VHL ZRANB1	70 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GMNC GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A LATS2 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF
Entrez ID		22836	898
HPRD ID		09557	00455
Ensembl ID		ENSG00000164292	ENSG00000105173
Uniprot IDs		O94955	A0A0G3DHS8 P24864 V5W5X2
PDB IDs			1W98 5L2W
Enriched GO Terms of Interacting Partners?
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