FKBP1A and ABI2

Data Source:
BioGRID (two hybrid)

		FKBP1A	ABI2
Description		FKBP prolyl isomerase 1A	abl interactor 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Extrinsic Component Of Organelle Membrane Cytoplasmic Side Of Membrane Ryanodine Receptor Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Adherens Junction Lamellipodium SCAR Complex Filopodium Tip Dendritic Spine
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Macrolide Binding FK506 Binding Calcium Channel Inhibitor Activity Type I Transforming Growth Factor Beta Receptor Binding Ion Channel Binding SMAD Binding Activin Binding	Protein Binding Cytoskeletal Anchor Activity SH3 Domain Binding Kinase Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Proline-rich Region Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Heart Morphogenesis Protein Folding 'de Novo' Protein Folding SMAD Protein Complex Assembly Protein Maturation By Protein Folding Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Negative Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Protein Localization Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune Response Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Heart Trabecula Formation Chaperone-mediated Protein Folding Calcium Ion Transmembrane Transport Supramolecular Fiber Organization Negative Regulation Of Transforming Growth Factor Beta1 Activation Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation	Cytoskeleton Organization Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Viral Process Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Dendritic Spine Morphogenesis Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		mTORC1-mediated signalling Calcineurin activates NFAT Calcineurin activates NFAT TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR1 LBD Mutants in Cancer Potential therapeutics for SARS	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Pimecrolimus Tacrolimus Sirolimus (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl glucoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-hydroxybutan-2-one GPI-1485 Myristic acid (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE Dorsomorphin
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Butyrylcholinesterase levels ( 21862451) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subclinical atherosclerosis traits (other) ( 17903303) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Trunk fat mass ( 28552196) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		30 interacting genes: ABI2 ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A CDC42 DHFR ERBB2 ERBB3 ERBB4 FKBP4 GLMN HSP90AA1 ITPR1 MAPT MDM2 MID1 MTOR NLGN3 PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1	197 interacting genes: ABI1 ABI3 ABL1 ABL2 ABLIM3 ADAM19 AKAP8L AKAP9 ANKRD55 ANKS1A ARHGAP32 ARMC7 ATP23 BAG4 BIN3 BLOC1S5 BLOC1S6 BORCS6 C19orf54 C1orf109 C1orf216 C20orf202 C4orf17 CCDC102B CCDC115 CCDC57 CCDC74B CCHCR1 CDK6 CENPH CENPQ CEP44 CEP57 CLPP COG3 CRX CUEDC1 DCTN2 DISC1 DLGAP2 DLGAP4 DNAI7 DTNB EFS EGLN3 EGR4 EIF3H ENAH ENKD1 EPS8L1 FAM161B FAM166B FAM214B FAM90A1 FAM9C FBXL19 FHL5 FKBP1A FOXD4L1 GAS2L2 GCC1 GFAP GGN GPANK1 HGS HHEX HNRNPK HOMER3 HSF2BP IFT20 IHO1 INCA1 INO80B INSYN1 KHDRBS1 KIAA1217 KIFC3 KNSTRN KRT13 KRT14 KRT15 KRT19 KRT20 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT75 LENG1 LGALS9B LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LNX1 LURAP1 LZTS2 MAGEA1 MCM7 MED10 MED11 MED29 MEOX2 MRFAP1 MRFAP1L1 MRPL28 MRPL44 MYO15B MYOG MYOZ3 NCK1 NCK2 NCKIPSD NFASC NHSL2 NME4 NUP62 OIP5 OOEP PAK2 PCM1 PDLIM7 PFDN5 PHETA1 PHF1 PIN1 PLEKHN1 POMC PPIF PPP3CA PRAM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA1 PWWP2B RABEP1 RABGEF1 RASD1 RNPS1 RPP25 RSPH14 RUSC1 SCGN SDCBP SH3BP1 SH3KBP1 SLA SMARCB1 SMARCD1 SNAP23 SNAP91 SNAPIN SNX18 SNX7 SORBS3 STAM2 STX19 STX4 TFIP11 TLE5 TPM2 TRAF3IP1 TRIM32 TRIM72 TRIML2 TRIP6 UBQLN2 USHBP1 USP2 VARS2 VASP VCL VPS28 VPS37C WASF2 WASF3 WASHC1 WASHC3 WASL WIPF1 WWOX ZFP90 ZMYND12 ZNF474 ZNF688
Entrez ID		2280	10152
HPRD ID		01741	07338
Ensembl ID		ENSG00000088832	ENSG00000138443
Uniprot IDs		A0A087WTS4 P62942 Q0VDC6	A0A0C4DG21 A0A7D9NKC8 B7Z836 F8WAL6 Q9NYB9
PDB IDs		1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2ND5 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX 4N19 4ODP 4ODQ 4ODR 5I7P 5I7Q 6I1S 6M4U 6OQA	2ED0 3P8C 4N78
Enriched GO Terms of Interacting Partners?
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