FES and BCR

Data Source:
HPRD (in vitro, in vivo)

		FES	BCR
Description		FES proto-oncogene, tyrosine kinase	BCR activator of RhoGEF and GTPase
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Microtubule Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle	Cytosol Membrane Axon Protein-containing Complex Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Microtubule Binding Immunoglobulin Receptor Binding Phosphatidylinositol Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Microtubule Bundle Formation Chemotaxis Centrosome Cycle Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Regulation Of Cell Population Proliferation Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Monocyte Differentiation Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Cellular Response To Vitamin D Regulation Of Cell Motility Positive Regulation Of Actin Cytoskeleton Reorganization	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Keratinocyte Differentiation Regulation Of Rho Protein Signal Transduction Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	Signaling by cytosolic FGFR1 fusion mutants Rho GTPase cycle Signaling by FGFR1 in disease
Drugs		Fostamatinib	Imatinib Dasatinib Bosutinib Ponatinib
Diseases			Chronic myeloid leukemia (CML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Hypertension ( 31879980 21909115) Ischemic stroke ( 29531354) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 26343387) Number of sexual partners ( 30643258) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Schizophrenia ( 25056061 29483656 30285260) Stroke ( 29531354) Systolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369) Left-handedness ( 32989287)
Interacting Genes		40 interacting genes: APP AR BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR ERBB2 ERBB3 ERBB4 FKBP4 FKBP5 GAB1 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 KIT MDFI MET NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 SMURF1 STAT3 TERF1 TRIM28 ZNF746 ZNF775	45 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		2242	613
HPRD ID		01814	01044
Ensembl ID		ENSG00000182511	ENSG00000186716
Uniprot IDs		A0A024RC92 P07332	P11274
PDB IDs		1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93 6JMF	1K1F 2AIN 5N6R 5N7E 5OC7
Enriched GO Terms of Interacting Partners?
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