FBP1 and FLCN

Data Source:
BioGRID (two hybrid)

		FBP1	FLCN
Description		fructose-bisphosphatase 1	folliculin
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Cytosol Plasma Membrane Cilium Midbody Cell-cell Contact Zone Mitotic Spindle
	Molecular Function	RNA Polymerase II Transcription Factor Binding Protein Binding AMP Binding Fructose 1,6-bisphosphate 1-phosphatase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Sucrose Biosynthetic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Dephosphorylation Negative Regulation Of Cell Growth Fructose 1,6-bisphosphate Metabolic Process Cellular Response To Drug Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Cellular Response To Magnesium Ion	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell-cell Junction Assembly Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrion Organization Hemopoiesis Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Regulation Of Cytokinesis Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Regulation Of Histone Acetylation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Regulation Of Pro-B Cell Differentiation Negative Regulation Of ATP Biosynthetic Process
Pathways		Gluconeogenesis	Amino acids regulate mTORC1
Drugs		Adenosine phosphate 2,5-Anhydroglucitol-1,6-Biphosphate {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Mdl-29951 Fructose-6-phosphate MB-07803 Managlinat dialanetil N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE
Diseases		Fructose-1,6-bisphosphatase deficiency	Renal cell carcinoma Birt-Hogg-Dube syndrome
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Colorectal or endometrial cancer ( 26621817) Obesity-related traits ( 23251661)	Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		38 interacting genes: ACTN1 APC ASCC2 ASL ATP5MF AXIN2 BCL10 BCL2L1 BIN1 BMPR1A BRAF BUB1 CSNK1E CTNNA1 DCC DYNC1I1 ERBB2 FBP2 FBXW7 FLCN FXR2 HDAC6 HSPA8 KLRC2 LNX1 MLH3 MSH2 PCNX4 POT1 PRKN PTK2 PTPRJ RB1 RNF183 STK11 TERF1 TLR2 TRIM28	11 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS TMEFF1 TSTD2
Entrez ID		2203	201163
HPRD ID		01973	06278
Ensembl ID		ENSG00000165140	ENSG00000154803
Uniprot IDs		P09467 Q2TU34	A0A0S2Z5Y7 Q8NFG4
PDB IDs		1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 5ZWK 6LS5 6LW2 7CVN	3V42 6NZD 6ULG
Enriched GO Terms of Interacting Partners?
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