DDIAS and ACLY

Data Source:
BioGRID (two hybrid)

		DDIAS	ACLY
Description		DNA damage induced apoptosis suppressor	ATP citrate lyase
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus Cytoplasm	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Molecular_function	ATP Citrate Synthase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Apoptotic Process Mitotic Cell Cycle Arrest Regulation Of DNA Stability Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Acetyl-CoA Biosynthetic Process Citrate Metabolic Process Oxaloacetate Metabolic Process Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process Positive Regulation Of Cellular Metabolic Process Neutrophil Degranulation Fatty-acyl-CoA Biosynthetic Process
Pathways			ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis
Drugs			Bempedoic acid
Diseases
GWAS			High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		10 interacting genes: ACLY ACTN1 ACTN4 CBY1 ECM1 EFEMP1 FBLN1 MAF1 MIF4GD PLSCR1	8 interacting genes: APP CDKN2A CUL3 DDIAS GSK3B HGS KLHL25 PRKACA
Entrez ID		220042	47
HPRD ID		08062	00155
Ensembl ID		ENSG00000165490	ENSG00000131473
Uniprot IDs		B4DMA1 Q8IXT1	A0A024R1T9 A0A024R1Y2 P53396 Q4LE36
PDB IDs			3MWD 3MWE 3PFF 5TDE 5TDF 5TDM 5TDZ 5TE1 5TEQ 5TES 5TET 6HXH 6HXK 6HXL 6HXM 6O0H 6POE 6POF 6QFB 6UI9 6UIA 6UUW 6UUZ 6UV5
Enriched GO Terms of Interacting Partners?
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